资源类型

期刊论文 51

年份

2023 2

2022 5

2021 7

2020 3

2018 1

2017 6

2016 3

2015 3

2013 1

2012 3

2011 3

2010 4

2009 3

2008 2

2007 2

2005 1

2003 1

1999 1

展开 ︾

关键词

pH值 2

H2S 1

P4 1

PH3 1

上游关键敏感区 1

云无线接入网；智能反射面；传输波束成形；前传压缩 1

低影响开发 1

侧流免疫检测试纸条 1

催化剂 1

催化氧化 1

可降解塑料 1

四极杆质谱仪 1

固定床 1

地下水 1

地理信息系统 1

城市快速路 1

大鼠脑神经膜 1

子带瞬时能量谱 1

工业互联网 1

展开 ︾

检索范围：

排序： 展示方式：

Aptamer-coded DNA nanoparticles for targeted doxorubicin delivery using pH-sensitive spacer

Pengwei Zhang, Junxiao Ye, Ergang Liu, Lu Sun, Jiacheng Zhang, Seung Jin Lee, Junbo Gong, Huining He, Victor C. Yang

《化学科学与工程前沿（英文）》 2017年 第11卷 第4期   页码 529-536 doi: 10.1007/s11705-017-1645-z

摘要： An anticancer drug delivery system consisting of DNA nanoparticles synthesized by rolling circle amplification (RCA) was developed for prostate cancer membrane antigen (PSMA) targeted cancer therapy. The template of RCA was a DNA oligodeoxynucleotide coded with PSMA-targeted aptamer, drug-loading domain, primer binding site and pH-sensitive spacer. Anticancer drug doxorubicin, as the model drug, was loaded into the drug-loading domain (multiple GC-pair sequences) of the DNA nanoparticles by intercalation. Due to the integrated pH-sensitive spacers in the nanoparticles, in an acidic environment, the cumulative release of doxorubicin was far more than the cumulative release of the drug in the normal physiological environment. In cell uptake experiments, treated with doxorubicin loaded DNA nanoparticles, PSMA-positive C4-2 cells could take up more doxorubicin than PSMA-null PC-3 cells. The prepared DNA nanoparticles showed the potential as drug delivery system for PSMA targeting prostate cancer therapy.

关键词： aptamer     DNA nanoparticles     rolling circle amplification     doxorubicin     drug delivery     pH sensitive    

HTML PDF 收藏

The molecular epidemiological study of colistin-only-sensitive strains in multi-drug resistant Acinetobacter

YANG Li, HAN Lizhong, SUN Jingyong, NI Yuxing, YU Yunsong

《医学前沿（英文）》 2007年 第1卷 第4期   页码 423-428 doi: 10.1007/s11684-007-0083-6

摘要： This paper reported the epidemiology of the colistin-only-sensitive (COS-AB) in a tertiary teaching hospital in China. We analyzed the clinical data of 136 COS-AB isolates from June 2004 to May 2005 and collected 66 . isolates in which 33 strains were COS-AB, and the rest were non-COS-AB. Random amplified polymorphic DNA (RAPD) analysis (primer ERIC2 and 272) showed that all COS-AB were identical, while pulsed-field gel electrophotesis (PFGE) analysis showed two separate genotypes of these COS-AB which were distinctly different from that of non-COS-AB. The COS-AB from burn wards showed the identical PFGE pattern which was distinguished from the genotype of COS-AB in other departments, mainly surgical systems. The cross-infection was severe and strict methods of disinfection and sterilization should be implemented. Meanwhile, the epidemiology of COS-AB in environment and patients should be closely monitored. The PFGE analysis is a reliable method of . typing.

关键词： identical     different     teaching hospital     genotype     colistin-only-sensitive    

HTML PDF 收藏

Carbon dots-based fluorescence sensor for two-photon imaging of pH in diabetic mice

《化学科学与工程前沿（英文）》 2023年 第17卷 第3期   页码 298-306 doi: 10.1007/s11705-022-2212-9

摘要： Herein, a reversible pH fluorescent sensor was developed using caffeic acid as the precursor by one-step solvothermal synthesis method. The carbon dots-based sensor (CA-CDs) exhibited pH-dependent increase in fluorescence intensity and showed linear relationship in the range of pH 6.60 and 8.00. Notably, the fluorescence sensor has a reversible response to pH change. Finally, the CA-CDs has been successfully applied for two-photon imaging of the pH in liver and kidney of diabetic mice. Imaging results showed that the pH value in kidney of diabetic mice was lower than that of the normal mice, while the pH value in liver of diabetic mice was almost the same as that of the normal mice. The present study provides a simple analytical method for pH detection suitable for in vivo.

关键词： carbon dots     two-photon imaging     pH     diabetic mice    

HTML PDF 收藏

Near-infrared benzodiazoles as small molecule environmentally-sensitive fluorophores

《化学科学与工程前沿（英文）》 2022年 第16卷 第1期   页码 128-135 doi: 10.1007/s11705-021-2080-8

摘要： The development of fluorophores emitting in the near-infrared spectral window has gained increased attention given their suitable features for biological imaging. In this work, we have optimised a general and straightforward synthetic approach to prepare a small library of near-infrared-emitting C-bridged nitrobenzodiazoles using commercial precursors. C-bridged benzodiazoles have low molecular weight and neutral character as important features that are not common in most near-infrared dyes. We have investigated their fluorescence response in the presence of a wide array of 60 different biomolecules and identified compound 3i as a potential chemosensor to discriminate between Fe2+ and Fe3+ ions in aqueous media.

关键词： fluorescence     probes     iron     screening     library    

HTML PDF 收藏

基于代价敏感学习的实体-关系联合知识嵌入 Article

Sheng-kang YU, Xue-yi ZHAO, Xi LI, Zhong-fei ZHANG

《信息与电子工程前沿（英文）》 2017年 第18卷 第11期   页码 1867-1873 doi: 10.1631/FITEE.1601255

摘要： 我们将实体嵌入问题看作同时完成两个不同但相关的嵌入任务（实体嵌入和关系嵌入）的联合优化问题，并在联合嵌入框架下求解该问题。在该嵌入框架下，我们设计了联合评分函数，用以对实体和关系间的相关性实例进行量化评价，并将评分函数融入最大间隔学习方法中，使用知识库中的上下文信息学习实体与关系的嵌入向量。通过求解联合优化问题，我们的设计有效地表达了嵌入空间的固有拓扑结构。实验结果证实了我们的嵌入框架在表达不同关系的语义相关性和进行知识推理中的关系预测时的有效性。

关键词： 知识嵌入；联合嵌入；代价敏感学习    

HTML PDF 收藏

Fifty Years of Water Sensitive Urban Design, Salisbury, South Australia

John C. Radcliffe, Declan Page, Bruce Naumann, Peter Dillon

《环境科学与工程前沿（英文）》 2017年 第11卷 第4期 doi: 10.1007/s11783-017-0937-3

摘要： Australia has developed extensive policies and guidelines for the management of its water. The City of Salisbury, located within metropolitan Adelaide, South Australia, developed rapidly through urbanisation from the 1970s. Water sensitive urban design principles were adopted to maximise the use of the increased run-off generated by urbanisation and ameliorate flood risk. Managed aquifer recharge was introduced for storing remediated low-salinity stormwater by aquifer storage and recovery (ASR) in a brackish aquifer for subsequent irrigation. This paper outlines how a municipal government has progressively adopted principles of Water Sensitive Urban Design during its development within a framework of evolving national water policies. Salisbury’s success with stormwater harvesting led to the formation of a pioneering water business that includes linking projects from nine sites to provide a non-potable supply of 5 × 10 m ·year . These installations hosted a number of applied research projects addressing well configuration, water quality, reliability and economics and facilitated the evaluation of its system as a potential potable water source. The evaluation showed that while untreated stormwater contained contaminants, subsurface storage and end-use controls were sufficient to make recovered water safe for public open space irrigation, and with chlorination, acceptable for third pipe supplies. Drinking water quality could be achieved by adding microfiltration, disinfection with UV and chlorination. The costs that would need to be expended to achieve drinking water safety standards were found to be considerably less than the cost of establishing dual pipe distribution systems. The full cost of supply was determined to be AUD$1.57 m for non-potable water for public open space irrigation, much cheaper than mains water, AUD$3.45 m at that time. Producing and storing potable water was found to cost AUD$1.96 to $2.24 m .

关键词： Managed Aquifer Recharge (MAR)     Stormwater harvesting     Water recycling drinking water     Low impact development     Water sensitive urban design    

HTML PDF 收藏

Sorption of tetracycline to sediments and soils: assessing the roles of pH, the presence of cadmium and

Guixiang ZHANG, Xitao LIU, Ke SUN, Ye ZHAO, Chunye LIN

《环境科学与工程前沿（英文）》 2010年 第4卷 第4期   页码 421-429 doi: 10.1007/s11783-010-0265-3

摘要： Batch sorption experiments were conducted to evaluate the sorption behavior of tetracycline (TC, H L) on sediments and soils in the presence and absence of cadmium (Cd), as affected by pH and properties of sediments and soils. The results indicated stronger nonlinearity and higher capacity of TC sorption on sediments than on soils. Sorption of TC also strongly depended on environmental factors and sediment/soil properties. Lower pH facilitated TC sorption through a cation exchange mechanism, which also took place at pH values above 5.5, where TC existed as a zwitterion (H L ) or anions (HL and L ). When pH was above 7, however, ligand-promoted dissolution of TC might occur due to TC weakening the Al-O bond of aluminum oxide and the Fe-O bond of iron oxide. Natural organic matter (NOM) plays a more important role in TC sorption than cation exchange capacity (CEC) and clay contents. The presence of Cd (II) increased TC sorption on both sediments and soils, which resulted from the decrease of equilibrium solution pH caused by Cd exchange with H ions of sediment/soil surfaces. The increase of TC sorption was also related to the formation of TC-Cd complexes, where Cd acted as a bridge between the sediment/soil and TC.

关键词： sorption     tetracycline (TC)     pH     cadmium (Cd)     antibiotic    

HTML PDF 收藏

Effect of pH on biologic degradation of

Hongjing LI, Mengli HAO, Jingxian LIU, Chen CHEN, Zhengqiu FAN, Xiangrong WANG

《环境科学与工程前沿（英文）》 2012年 第6卷 第2期   页码 224-230 doi: 10.1007/s11783-011-0314-6

摘要： In this paper, the effect of pH on biological degradation of by alga-lysing bacteria in laboratory-scale sequencing batch biofilm reactors (SBBRs) was investigated. After 10 d filming with waste activated sludge, the biological film could be formed, and the bioreactors in which laid polyolefin resin filler were used to treat algal culture. By comparing the removal efficiency of chlorophyll at different aerobic time, the optimum time was determined as 5 h. Under pH 6.5, 7.5, and 8.5 conditions, the removal rates of were respectively 75.9%, 83.6%, and 78.3% (in term of chlorophyll ), and that of Chemical Oxygen Demand (COD ) were 30.6%, 35.8%, and 33.5%. While the removal efficiencies of ammonia nitrogen ( ) were all 100%. It was observed that the sequence of the removal efficiencies of algae, and organic matter were pH 7.5>pH 8.5>pH 6.5. The results showed that the dominant alga-lysing bacteria in the SBBRs was strain HM-01, which was identified as sp. by Polymerase Chain Reaction (PCR) amplification of the 16S rRNA gene, Basic Local Alignment Search Tool (BLAST) analysis, and comparison with sequences in the GenBank nucleotide database. The algicidal activated substance which HM-01 strain excreted could withstand high temperature and pressure, also had better hydrophily and stronger polarity.

关键词： pH     biological degradation     alga-lysing bacteria     sequencing batch biofilm reactor (SBBR)     16S rRNA     Bacillus sp    

HTML PDF 收藏

single-stranded DNA-reduced graphene oxide nanocomposites based electrochemical biosensor for highly sensitive

《化学科学与工程前沿（英文）》 2021年 第15卷 第6期   页码 1572-1582 doi: 10.1007/s11705-021-2112-4

摘要： High density and uniform distribution of the gold nanoparticles functionalized single-stranded DNA modified reduced graphene oxide nanocomposites were obtained by non-covalent interaction. The positive gold nanoparticles prepared by phase inversion method exhibited good dimensional homogeneity and dispersibility, which could readily combine with single-stranded DNA modified reduced graphene oxide nanocomposites by electrostatic interactions. The modification of single-stranded DNA endowed the reduced graphene oxide with favorable biocompatibility and provided the preferable surface with negative charge for further assembling of gold nanoparticles to obtain gold nanoparticles/single-stranded DNA modified reduced graphene oxide nanocomposites with better conductivity, larger specific surface area, biocompatibility and electrocatalytic characteristics. The as-prepared nanocomposites were applied as substrates for the construction of cholesterol oxidase modified electrode and well realized the direct electron transfer between the enzyme and electrode. The modified gold nanoparticles could further catalyze the products of cholesterol oxidation catalyzed by cholesterol oxidase, which was beneficial to the enzyme-catalyzed reaction. The as-fabricated bioelectrode exhibited excellent electrocatalytic performance for the cholesterol with a linear range of 7.5‒280.5 μmol·L‒1, a low detection limit of 2.1 μmol·L‒1, good stability and reproducibility. Moreover, the electrochemical biosensor showed good selectivity and acceptable accuracy for the detection of cholesterol in human serum samples.

关键词： reduced graphene oxide     gold nanoparticles     electrochemical biosensor     cholesterol oxidase     cholesterol    

HTML PDF 收藏

A Cu-modified active carbon fiber significantly promoted HS and PH simultaneous removal at a low reaction

《环境科学与工程前沿（英文）》 2021年 第15卷 第6期 doi: 10.1007/s11783-021-1425-3

摘要：

• Cu0.15-ACF performs the best for H2S and PH3 simultaneous removal.

关键词： ACF     H2S     PH3     Cu     Low temperature     Simultaneous removal    

HTML PDF 收藏

Decomposition of perfluorooctanoic acid by microwave-activated persulfate: Effects of temperature, pH

Yuchi LEE, Shanglien LO, Jeff KUO, Chinghong HSIEH

《环境科学与工程前沿（英文）》 2012年 第6卷 第1期   页码 17-25 doi: 10.1007/s11783-011-0371-x

摘要： Microwave-hydrothermal treatment of persistent and bioaccumulative perfluorooctanoic acid (PFOA) in water with persulfate ( ) has been found effective. However, applications of this process to effectively remediate PFOA pollution require a better understanding on free-radical scavenging reactions that also take place. The objectives of this study were to investigate the effects of pH (pH= 2.5, 6.6, 8.8, and 10.5), chloride concentrations (0.01–0.15 mol·L ), and temperature (60°C, 90°C, and 130°C) on persulfate oxidation of PFOA under microwave irradiation. Maximum PFOA degradation occurred at pH 2.5, while little or no degradation at pH 10.5. Lowering system pH resulted in an increase in PFOA degradation rate. Both high pH and chloride concentrations would result in more scavenging of sulfate free radicals and slow down PFOA degradation. When chloride concentrations were less than 0.04 mol·L at 90°C and 0.06 mol·L at 60°C, presence of chloride ions had insignificant impacts on PFOA degradation. However, beyond these concentration levels, PFOA degradation rates reduced significantly with an increase in chloride concentrations, especially under the higher temperature.

关键词： microwave     perfluorooctanoic acid     pH     persulfate     chloride ions     perfluorocarboxylic acids    

HTML PDF 收藏

Co-fermentation of waste activated sludge with food waste for short-chain fatty acids production: effect of pH

Leiyu FENG, Yuanyuan YAN, Yinguang CHEN

《环境科学与工程前沿（英文）》 2011年 第5卷 第4期   页码 623-632 doi: 10.1007/s11783-011-0334-2

摘要： Effect of pH ranging from 4.0 to 11.0 on co-fermentation of waste activated sludge (WAS) with food waste for short-chain fatty acids (SCFAs) production at ambient temperature was investigated in this study. Experimental results showed that the addition of food waste significantly improved the performance of WAS fermentation system, which resulted in the increases of SCFAs production and substrate reduction. The SCFAs production at pH 6.0, 7.0, 8.0, and 9.0 and fermentation time of 4 d was respectively 5022.7, 6540.5, 8236.6, and 7911.7 mg COD·L , whereas in the blank tests (no pH adjustment, pH 8.0 (blank test 1), no food waste addition, pH 8.0 (blank test 2), and no WAS addition (blank test 3)) it was only 1006.9, 971.1, and 1468.5 mg COD·L , respectively. The composition of SCFAs at pH from 6.0 to 9.0 was also different from other conditions and propionic acid was the most prevalent SCFA, which was followed by acetic and n-butyric acids, while acetic acid was the top product under other conditions. At pH 8.0 a higher volatile suspended solids (VSS) reduction of 16.6% for the mixture of WAS and food waste than the sole WAS indicated a synergistic effect existing in fermentation system with WAS and food waste. The influence of pH on the variations of nutrient content was also studied during anaerobic fermentation of the mixture of WAS and food waste at different pH conditions. The release of increased with fermentation time at all pH values investigated except 4.0, 5.0 and in blank test one. The concentrations of soluble phosphorus at acidic pHs and in the blank test one were higher than those obtained at alkaline pHs. Ammonia and phosphorus need to be removed before the SCFAs-enriched fermentation liquid from WAS and food waste was used as the carbon source.

关键词： waste activated sludge (WAS)     food waste     co-fermentation     short-chain fatty acids (SCFAs)     pH     synergistic effect    

HTML PDF 收藏

青藏高原“敏感区”对我国灾害天气气候的影响及其监测

徐祥德

《中国工程科学》 2009年 第11卷 第10期   页码 96-107

摘要：

根据中国区域大范围洪涝、暴雨、暴雪天气预报上游关键区，以及气候变化敏感区多圈层信息平台等重大需求。从“世界屋脊”青藏高原为灾害性天气上游关键区与气候信号敏感区的观点出发，提出高原及周边观测工程建网新思路与应用新技术方案，设计、构建了新一代气象综合观测预警长期监测系统，实现科学试验－工程建设－工程应用开发途径，发展高原及周边敏感区灾害天气上游早期预警系统监测平台，为灾害性天气预报与区域气候变化提供多功能业务服务应用平台；采用高原东缘南－北轴向观测数据信息（GPS监测站与AWS站）应用于改进WRF（weather research and forecasts）模式三维变分方案，实现了模式优化站网信息的同化技术，可提升中国区域暴雨、南方雪灾模式预报能力。针对夏季暴雨、南方暴雪，检验、证明了高原观测工程布网“早期预警”的显著效果。

关键词： 青藏高原     上游关键敏感区     灾害天气     早期预警    

HTML PDF 收藏

Tuning the electronic structure of NiCoP arrays through V doping for pH-universal hydrogen evolution

Yu Lin, Jinlei Wang, Duanlin Cao, Yaqiong Gong

《化学科学与工程前沿（英文）》 2021年 第15卷 第5期   页码 1134-1146 doi: 10.1007/s11705-020-2014-x

摘要： The exploration of cost-effective, high-performance, and stable electrocatalysts for the hydrogen evolution reaction (HER) over wide pH range (0–14) is of paramount importance for future renewable energy conversion technologies. Regulation of electronic structure through doping vanadium atoms is a feasible construction strategy to enhance catalytic activities, electron transfer capability, and stability of the HER electrode. Herein, V-doped NiCoP nanosheets on carbon fiber paper (CFP) (denoted as V -NiCoP/CFP) were constructed by doping V modulation on NiCoP nanosheets on CFP and used for pH-universal HER. Benefiting from the abundant catalytic sites and optimized hydrogen binding thermodynamics, the resultant V -NiCoP/CFP demonstrates a significantly improved HER catalytic activity, requiring overpotentials of 46.5, 52.4, and 85.3 mV to reach a current density of 10 mA·cm in 1 mol·L KOH, 0.5 mol·L H SO , and 1 mol·L phosphate buffer solution (PBS) electrolytes, respectively. This proposed cation-doping strategy provides a new inspiration to rationally enhance or design new-type nonprecious metal-based, highly efficient, and pH-universal electrocatalysts for various energy conversion systems.

关键词： hydrogen evolution reaction     transition metal phosphides     pH-universal     vanadium doping     carbon fiber paper    

HTML PDF 收藏

Cystine-assisted accumulation of gold nanoparticles on ZnO to construct a sensitive surface-enhanced

《化学科学与工程前沿（英文）》 2023年 第17卷 第1期   页码 15-23 doi: 10.1007/s11705-022-2177-8

摘要： Recently, various semiconductor/metal composites have been developed to fabricate surface-enhanced Raman spectroscopy substrates. However, low metal loading on semiconductors is still a challenge. In this study, cystine was introduced to increase the accumulation of gold nanoparticles on zinc oxide, owing to the biomineralization property of cystine. Morphological analysis revealed that the obtained ZnO/Au/cystine composite not only had a higher metal loading but also formed a porous structure, which is beneficial for Raman performance. Compared with ZnO/Au, the ZnO/Au/cystine substrate displayed a 40-fold enhancement in the Raman signal and a lower limit of detection (10–11 mol·L−1) in the detection of rhodamine 6G. Moreover, the substrate has favorable homogeneity and stability. Finally, ZnO/Au/cystine displayed excellent performance toward crystal violet and methylene blue in a test based on river water samples. This study provided a promising method to fabricate sensitive semiconductor/noble metal-based surface-enhanced Raman spectroscopy substrates for Raman detection.

关键词： biomineralization     cystine     semiconductor/metal composite     SERS detection     Raman detection    

HTML PDF 收藏

标题 作者 时间 类型 操作

Aptamer-coded DNA nanoparticles for targeted doxorubicin delivery using pH-sensitive spacer

Pengwei Zhang, Junxiao Ye, Ergang Liu, Lu Sun, Jiacheng Zhang, Seung Jin Lee, Junbo Gong, Huining He, Victor C. Yang

期刊论文

The molecular epidemiological study of colistin-only-sensitive strains in multi-drug resistant Acinetobacter

YANG Li, HAN Lizhong, SUN Jingyong, NI Yuxing, YU Yunsong

期刊论文

Carbon dots-based fluorescence sensor for two-photon imaging of pH in diabetic mice

期刊论文

Near-infrared benzodiazoles as small molecule environmentally-sensitive fluorophores

期刊论文

基于代价敏感学习的实体-关系联合知识嵌入

Sheng-kang YU, Xue-yi ZHAO, Xi LI, Zhong-fei ZHANG

期刊论文

Fifty Years of Water Sensitive Urban Design, Salisbury, South Australia

John C. Radcliffe, Declan Page, Bruce Naumann, Peter Dillon

期刊论文

Sorption of tetracycline to sediments and soils: assessing the roles of pH, the presence of cadmium and

Guixiang ZHANG, Xitao LIU, Ke SUN, Ye ZHAO, Chunye LIN

期刊论文

Effect of pH on biologic degradation of

Hongjing LI, Mengli HAO, Jingxian LIU, Chen CHEN, Zhengqiu FAN, Xiangrong WANG

期刊论文

single-stranded DNA-reduced graphene oxide nanocomposites based electrochemical biosensor for highly sensitive

期刊论文

A Cu-modified active carbon fiber significantly promoted HS and PH simultaneous removal at a low reaction

期刊论文

Decomposition of perfluorooctanoic acid by microwave-activated persulfate: Effects of temperature, pH

Yuchi LEE, Shanglien LO, Jeff KUO, Chinghong HSIEH

期刊论文

Co-fermentation of waste activated sludge with food waste for short-chain fatty acids production: effect of pH

Leiyu FENG, Yuanyuan YAN, Yinguang CHEN

期刊论文

青藏高原“敏感区”对我国灾害天气气候的影响及其监测

徐祥德

期刊论文

Tuning the electronic structure of NiCoP arrays through V doping for pH-universal hydrogen evolution

Yu Lin, Jinlei Wang, Duanlin Cao, Yaqiong Gong

期刊论文

Cystine-assisted accumulation of gold nanoparticles on ZnO to construct a sensitive surface-enhanced

期刊论文